Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells


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CD133-positive cells in hepatocellular carcinoma (HCC) display cancer stem cell (CSC)-like properties in addition to resistance to chemotherapeutic agents and radiation that is ionizing but, their function remains unknown. In this paper, we identified a hitherto unknown procedure to overcome CD133-induced resistance to therapy that is anticancer.


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We applied a alternate approach to enrich the CD133-positive HCC populace by manipulating 3D culture conditions. Body’s defence mechanism against reactive oxygen species (ROS) in CSC spheroids had been assessed by fluorescence image-based phenotypic screening system.

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